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MiniBRx®

The MiniBRx® is a high-throughput, single-use bioreactor system designed for suspension cell culture, a robust solution for process development and scale-down modeling. Its capability to conduct multiple experiments simultaneously makes it ideal for high-throughput screening and optimization.
MiniBRx<sup>®</sup>
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Configurations of

MiniBRx® Bioreactors

Our product is available in various configurations, designed to meet your specific bioprocessing needs. Explore the variants of MiniBRx®:

MiniBRx® : Fed-Batch

The Fed-Batch MiniBRx® is optimized for applications requiring controlled nutrient addition and precise management of cell growth and product yield. This system allows gradual nutrient feed, enhancing cell productivity while minimizing waste accumulation. Perfect for process optimization, scale-up studies, and Quality by Design (QbD) experiments, the Fed-Batch MiniBRx® provides a compact, cost-effective solution for bioprocess development. It reduces media and reagent consumption, making it ideal for researchers and manufacturers seeking high-quality results at reduced operational costs.

MiniBRx® : Perfusion

The Perfusion-Enabled MiniBRx® supports high cell density cultures by continuously providing nutrients and removing waste, ensuring long-term cell viability and consistent productivity. Ideal for processes like monoclonal antibody production and vaccine manufacturing, it maintains stable performance for extended production runs. The integration of high-flux tangential flow filtration (HFTFF) further enhances its efficiency, making it an essential tool for advanced bioprocessing that demands both high productivity and stability.

Key Features & Advantages

Discover the features that make MiniBRx® the preferred choice for bioprocessing:

  • High-Throughput Capability:

    With the MiniBRx®, you can run up to 8 mini bioreactors in parallel, enabling high-throughput screening and rapid optimization. This allows you to conduct multiple experiments at once, saving time and resources while speeding up process development.

  • Scale-Down Modeling:

    The MiniBRx® accurately replicates large-scale conditions in a compact, benchtop format, making it ideal for Quality by Design (QbD) and Design of Experiments (DoE) studies. This ensures you can smoothly transition from lab-scale research to commercial production with confidence.

  • Advanced Automation:

    The MiniBRx® offers integrated automation for precise control over critical parameters like pH, temperature, dissolved oxygen (DO), and agitation. Its user-friendly SCADA software simplifies setup, monitoring, and data logging, giving you consistent and reliable results every time.

  • Flexible Configurations:

    Whether you need fed-batch or perfusion-enabled systems, the MiniBRx® adapts to your bioprocessing needs. With customizable impellers and aeration options, you can achieve optimal mixing and mass transfer for enhanced process efficiency.

  • Cost-Effective Design:

    The MiniBRx® helps you reduce media and reagent usage, lowering operational costs. Its compact benchtop design also maximizes your lab space, making it a practical and economical choice for your workflows.

Applications

From perfusion optimization to personalized medicine, explore our diverse applications for pioneering bioprocessing features:
  • mAbs & Biosimilars

    mAbs & Biosimilars

    Robust & scalable platforms for mAbs production using CHO or other expression systems, optimized for high-density fed-batch & perfusion processes.

  • Car-T & Car-NK cell therapies

    Car-T & Car-NK cell therapies

    Closed, integrated platforms supporting autologous & allogeneic cell therapy workflows, from transduction and expansion to harvest.

  • Viral Vectors

    Viral Vectors

    Designed for high-yield production of Lentiviral & AAV vectors, bioreactor systems ensure controlled productivity from bench to clinical scale.

  • Therapeutic proteins & Hormones

    Therapeutic proteins & Hormones

    Versatile bioreactor systems for recombinant protein expression in mammalian hosts, ensuring consistent process control and production yield.

  • Organoids

    Organoids

    Advanced bioreactor configurations for organoid growth & 3D tissue modeling, enabling nutrient uniformity, gas exchange, and structural integrity.

  • Stem Cells

    Stem Cells

    Single-use bioreactors designed for consistent expansion and cell recovery of stem cells in adherent & suspension formats.

Technical Support Documents

We provide comprehensive technical support to help you get the most out of your MiniBRx® system. Explore our resources, including:

  • Brochures
  • Application Notes
  • Specification Sheets
  • Webinars
  • Scientific Resources
  • User Guides & Manuals
  • 01 MiniBRx Perfusion System _ Brochure

Do You Need A Demo?

Get expert guidance for your biotech needs. Our seasoned professionals offer tailored solutions to propel your bioprocessing endeavors forward.

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Frequently Asked Questions

What sensors and monitoring capabilities are integrated into the MiniBRx system?

Each MiniBRx unit includes single-use optical sensors for pH, DO, temperature, and optional sensors for glucose, lactate, pCO₂, and biomass. The system also offers advanced SCADA-based process control and complies with 21 CFR Part 11 & CSV for data integrity and regulatory compliance.

Can MiniBRx support both fed-batch and perfusion processes?

Yes. The MiniBRx platforms are available in configurations that support either fed-batch or both fed-batch and integrated perfusion modes, including HF-TFF modules for continuous media exchange, making it suitable for a wide variety of upstream process development applications. It is to be noted that the MiniBRx Quad docking station with perfusion capability can support fed-batch bioprocessing, but the fed-batch docking station can not support perfusion-based bioprocessing. However, the fed-batch docking station can easily be upgraded to perfusion platform by OmniBRx team.

How many bioreactors can be operated simultaneously using MiniBRx?

The MiniBRx system supports up to 8 independently controlled mini-bioreactors using 2 units of MiniBRx Quad docking stations (eighter Fed-batch or perfusion), allowing researchers to conduct multiple parallel experiments under identical or varying conditions, significantly reducing development timelines and cost per experiment.

Can MiniBRx Be Connected to Automated Sampling Devices for Online Cell Count & Metabolite Analysis?

Yes, the MiniBRx platform can be integrated with automated sampling devices for real-time monitoring of cell density, viability, and metabolite concentrations such as glucose, lactate, pCO₂ and many more. The system features modular sensor ports, peristaltic pumps, and SCADA-based control, allowing seamless connectivity with third-party automated samplers, online analyzers, and PAT tools. This integration enables continuous data acquisition, reduces manual sampling errors, and supports real-time decision-making during process development. Whether for clone screening, perfusion optimization, or scale-down modeling, automated analytics enhance the precision and throughput of experiments conducted on the MiniBRx platform.

What services and support OmniBRx can provide along with the MiniBRx system?

OmniBRx offers full process consultation, operator training, commissioning support, and contract development services to ensure optimal setup and use of the MiniBRx system for your specific application. Optionally, OmniBRx team can support for DQ, FAT, IQ, OQ, and PQ, along with GMP documentation and CSV compliance. It is designed to meet the standards required for regulated environments. The MiniBRx system supports OPC-UA connectivity, optional secure network integration, and a SCADA software that aligns with company networks and regulatory data handling requirements.

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