Highlights and Benefits

  • Integrated perfusion processing with recipe based automation for cell harvesting
  • Pre-installed calibrated probes and no oxygen sparging needed
  • USP Class VI certified materials
  • Customized treatment for cells adherence
  • Special considerations for allogenic stem cell culture processing for cell and gene therapy applications.
  • Single-use format (ease of handling and validations)

CellBRx™ 5L bioreactor systems are more advisable for Allogenic Stem cell production on larger scale. The 5L scale bioreactor vessel accommodates approximately 10 m2 of surface area which is equivalent to the use of 16 No’s of Cell Factories (CF-10). This 5L scale single-use culture vessel can support the growth and production of around 330 billion stem cells and automated recovery of this stem cells in to harvest without causing any shear forces and harsh treatments.

FEATURES

  • Integrated mixing system for evenly-distributed media circulation and low shear stress.
  • Specially treated cell carriers specifically adapted to variety of adherent cell cultures.
  • Unique DBR technology to ensure efficient mixing and homogeneity.
  • Single-use bioreactor made from USP Class VI and ISO 10993 approved rigid plastic to ensure process reliability.
  • Modular size of dynamic bed from 0.5 L to 200L offering several customized configurations at small and large scale.
  • Completely single-use closed bioreactor from vessel to sensor for sterility and contamination risk reduction.
  • Ensured reproducibility and traceability of cell cultures by monitoring and control of culture parameters including pH, DO, temperature, glucose, biomass etc.
  • Designed for use in a complete closed system from seeding to harvest.
  • Processing flexibility with reduction of numbers of operations, complexity and risks related to operations (e.g. , cell, seeding, medium exchange, harvest)

Equivalent units of conventional technologies (Surface area comparison)

Roller Bottles (1050 cm2)
11.8
Cell Factories (CF10)
11.8
Packed Bed Bioreactors
0.002
Microcarriers in 100L STRs
0.01
Roller Bottles (1050 cm2)
118
Cell Factories (CF10)
16
Packed Bed Bioreactors
0.02
Microcarriers in 100L STRs
0.05
Roller Bottles (1050 cm2)
2941
Cell Factories (CF10)
391
Packed Bed Bioreactors
0.5
Microcarriers in 100L STRs
1.14
Roller Bottles (1050 cm2)
17647
Cell Factories (CF10)
2344
Packed Bed Bioreactors
3
Microcarriers in 100L STRs
6.82

Equivalent units of conventional technologies (Surface area comparison)

Roller Bottles (1050 cm2)
11.8
Cell Factories (CF10)
11.8
Packed Bed Bioreactors
0.002
Microcarriers in 100L STRs
0.01
Roller Bottles (1050 cm2)
118
Cell Factories (CF10)
16
Packed Bed Bioreactors
0.02
Microcarriers in 100L STRs
0.05
Roller Bottles (1050 cm2)
2941
Cell Factories (CF10)
391
Packed Bed Bioreactors
0.5
Microcarriers in 100L STRs
1.14
Roller Bottles (1050 cm2)
17647
Cell Factories (CF10)
2344
Packed Bed Bioreactors
3
Microcarriers in 100L STRs
6.82

The CellBRx™ 5L system is pilot scale bioreactor accommodate 5L capacity culture vessels (readily available) for pilot scale studies and small scale manufacturing of biologics including recombinant therapeutics and vaccines.

Cost advantage (% reduction of upstream produciton cost)

Roller Bottles (1050 cm2)
Cell Factories (CF10)
77

%

Multi-plate Bioreactors
38

%

Packed Bed Bioreactors
Microcarriers in 100L STRs
Roller Bottles (1050 cm2)
38

%

Cell Factories (CF10)
92

%

Multi-plate Bioreactors
78

%

Packed Bed Bioreactors
Microcarriers in 100L STRs
Roller Bottles (1050 cm2)
73

%

Cell Factories (CF10)
97

%

Multi-plate Bioreactors
91

%

Packed Bed Bioreactors
35

%

Microcarriers in 100L STRs
26

%

Roller Bottles (1050 cm2)
88

%

Cell Factories (CF10)
99

%

Multi-plate Bioreactors
96

%

Packed Bed Bioreactors
72

%

Microcarriers in 100L STRs
68

%

Product datasheet

For more information on CellBRx™ 5L system please contact us