The CellBRx™ bioreactors are the first proud member of OmniBRx biotechnologies’ single use bioreactor family.

The CellBRx™ bioreactor are the world’s first fully-integrated perfusion driven, high cell density bioreactors designed to simplify adherent cell culture processes by combining the advantages of single-use technologies with the benefits of a dynamic-bed reactor technology. The compact system, designed for quick implementation and ease-of-use, represents a new generations of rigid wall single-use bioreactors. Central to The CellBRx™ bioreactors technology is the use of a compact and rotating dynamic-bed design, filled with custom disc shaped macrocarriers. This matrix discs are made of medical grade non-woven polyester microfibers (USP Class VI, ISO 10993 certifications) and provides surface area up to 1138 m2 available for cell growth in 100L bioreactor system. This surface area is equivalent of 11,269 Roller Bottles (1050 cm2 each)

The CellBRx™ bioreactor is provided with pre-packed and custom treated macrocarriers in support matrix. It alleviates delicate and time-consuming manual operations, reducing the overall process time and making the cell culture process more robust. While the cells are attached, grown and contained within the dynamic-bed support matrix, CellBRx™ bioreactors can be inoculated at the low cell densities.

Manual operations and consumables associated costs are greatly reduced, because of process simplification. Magnetically driven rotations of discs coupled with curved vanes in dynamic bed reactors ensures nutritional homogeneity and significantly lower mixing time. Dual integrated aeration systems i.e. purging gases in culture vessel overlay space and into the gas exchanger, supports gaseous requirements of the cultures without sparging of gases directly in culture medium and there by assures Stress-Free culture of sensitive cells while maintaining high kLa the in the bioreactor. As the cells are immobilized in the dynamic-bed matrix during perfusion processing, no centrifugation or filtration is needed to clarify the harvest broth which further simplifies and reduce downstream processing steps. Culture parameter control is automatic and integrated via single-use sensors for pH, dissolved oxygen, temperature, glucose(optical), lactate(optical) etc. To alleviate the bottlenecks of large-scale stem cell culture technologies, the CellBRx™ bioreactors offer the unique advantage of healthy cell recovery at large
scale using simple cell dissociation techniques.

Equivalent units of conventional technologies (Surface area comparison)

Roller Bottles (1050 cm2)
34
Cell Factories (CF10)
6
Multi-plate Bioreactors
0.3
Packed Bed Bioreactors
0.01
Microcarriers in 100L STRs
0.02
Roller Bottles (1050 cm2)
1776
Cell Factories (CF10)
295
Multi-plate Bioreactors
15
Packed Bed Bioreactors
0.4
Microcarriers in 100L STRs
0.8
Roller Bottles (1050 cm2)
11269
Cell Factories (CF10)
1872
Multi-plate Bioreactors
95
Packed Bed Bioreactors
2.4
Microcarriers in 100L STRs
5.4
Roller Bottles (1050 cm2)
45714
Cell Factories (CF10)
7595
Multi-plate Bioreactors
387
Packed Bed Bioreactors
10
Microcarriers in 100L STRs
22

Equivalent units of conventional technologies (Surface area comparison)

Roller Bottles (1050 cm2)
34
Cell Factories (CF10)
6
Multi-plate Bioreactors
0.3
Packed Bed Bioreactors
0.01
Microcarriers in 100L STRs
0.02
Roller Bottles (1050 cm2)
1776
Cell Factories (CF10)
295
Multi-plate Bioreactors
15
Packed Bed Bioreactors
0.4
Microcarriers in 100L STRs
0.8
Roller Bottles (1050 cm2)
11269
Cell Factories (CF10)
1872
Multi-plate Bioreactors
95
Packed Bed Bioreactors
2.4
Microcarriers in 100L STRs
5.4
Roller Bottles (1050 cm2)
45714
Cell Factories (CF10)
7595
Multi-plate Bioreactors
387
Packed Bed Bioreactors
10
Microcarriers in 100L STRs
22

We offer cell culture bioreactors with working volumes ranging from 0.2 L to 500 L. Our DBR technology based bioreactor systems are available for seed-train, process development, small- to pilot-scale production up to 10 L scale and for large-scale GMP manufacturing. Our global supply chain and rigorous in-house quality control procedures brings you the Scalable, Affordable, most Efficient and fully Customizable single-use bioreactors – the CellBRx ™.

Cost advantage (% reduction of upstream produciton cost)

Roller Bottles (1050 cm2)
Cell Factories (CF10)
76.1

%

Multi-plate Bioreactors
37.4

%

Packed Bed Bioreactors
Microcarriers in 100L STRs
Roller Bottles (1050 cm2)
37.4

%

Cell Factories (CF10)
91.5

%

Multi-plate Bioreactors
77.8

%

Packed Bed Bioreactors
Microcarriers in 100L STRs
Roller Bottles (1050 cm2)
72.4

%

Cell Factories (CF10)
96.3

%

Multi-plate Bioreactors
90.2

%

Packed Bed Bioreactors
34.3

%

Microcarriers in 100L STRs
25.6

%

Roller Bottles (1050 cm2)
87.8

%

Cell Factories (CF10)
98.4

%

Multi-plate Bioreactors
95.7

%

Packed Bed Bioreactors
71.1

%

Microcarriers in 100L STRs
67.3

%

Cost advantage (% reduction of upstream produciton cost)

Roller Bottles (1050 cm2)
Cell Factories (CF10)
77

%

Multi-plate Bioreactors
38

%

Packed Bed Bioreactors
Microcarriers in 100L STRs
Roller Bottles (1050 cm2)
38

%

Cell Factories (CF10)
92

%

Multi-plate Bioreactors
78

%

Packed Bed Bioreactors
Microcarriers in 100L STRs
Roller Bottles (1050 cm2)
73

%

Cell Factories (CF10)
97

%

Multi-plate Bioreactors
91

%

Packed Bed Bioreactors
35

%

Microcarriers in 100L STRs
26

%

Roller Bottles (1050 cm2)
88

%

Cell Factories (CF10)
99

%

Multi-plate Bioreactors
96

%

Packed Bed Bioreactors
72

%

Microcarriers in 100L STRs
68

%